Development of composition and quality assessment of pharmaceutical ointments with urea Emilia KLIMASZEWSKA University of Technology and Humanities in Radom Faculty of Medical Sciences and Health Sciences Department of Cosmetology, Małgorzata ZIĘBA, Ka

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Keywords:

pharmaceutical ointments, urea, quality 

Summary


The effect of urea concentration on selected physicochemical and functional properties of pharmaceutical ointments was analysed. Formulas were developed and stable ointments containing urea in concentration were produced: 0; 3; 5; 10 and 15% by weight. It was found that dynamic viscosity of the ointment, at constant temperature and pressure, changes with the applied forces, which allows to classify them as non-Newtonian systems. On the other hand, the flow limit of the tested ointments increases with the increase in urea concentration in the recipe. Moreover, these quantities correlate with measured changes in hardness and adhesion force and spreadability for tested samples. The influence of urea concentration on skin condition after ointment application with its participation was also noted. The application of urea at a concentration of 3-5% wt. in the tested ointments resulted in a significant increase in skin moisture compared to the reference ointment, without urea. Urea modifies the chemical structure of proteins, as a result of which it covers the place of water binding, thus increasing its content in the stratum corneum. This also results in a reduction of TEWL (Transepidermal Water Loss). The smallest water loss from the skin was recorded after application of an ointment containing 5% wt. urea. Due to these properties the application of the ointment with 3-5%wt. would be beneficial for dry and sensitive skin. On the other hand, the addition of urea in the lowest concentration used in the study (15% wt.) caused a slight increase in skin hydration and led to an increase in transepidermal water loss compared to the reference ointment, without urea. Urea in this case can be used for example in anti-acne preparations. It is also important that after the application of all ointments an increase in skin elasticity was observed in comparison to the ointment without urea.

 

Emilia KLIMASZEWSKA

University of Technology and Humanities in Radom Faculty of Medical Sciences and Health Sciences Department of Cosmetology,

Małgorzata ZIĘBA, Karolina PAWLIK

University of Technology and Humanities in Radom Faculty of Chemical Engineering and Commodity Science Department of Quality Sciences and Commodity Science